Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084163" target="_blank" >RIV/00216224:14110/15:00084163 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00063803

Result on the web

<a href="http://dx.doi.org/10.1007/s12263-015-0488-9" target="_blank" >http://dx.doi.org/10.1007/s12263-015-0488-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12263-015-0488-9" target="_blank" >10.1007/s12263-015-0488-9</a>

Result language

angličtina

Original language name

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Original language description

Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorphism in the miR-31/584 binding site of the AGT gene could influence body fat distribution. A total of 751 subjects (195 men, 556 women) were enrolled in the study. The rs7079 genotypes were determined by qRT-PCR. Anthropometric measurements were taken on all subjects, who were subsequently dividedinto two groups: obese ([30 kg m-2 ) and non-obese (30 kg m-2 ). Linear regression models were created to determine the contributions of sex, obesity status and rs7079 to all measured parameters. Adding the rs7079 genotype significantly contributed to the linear regression model for waist circumference (p = 0.013), hip circumference (p = 0.018) and supraspinal skin-fold thickness (p = 1 9 10-3 ). Differences between sexes and between the obese and nonobese groups were observed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes and Nutrition

ISSN

1555-8932

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1-7

UT code for WoS article

000360820100011

EID of the result in the Scopus database

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