All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00087060" target="_blank" >RIV/00216224:14110/15:00087060 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1093/jnci/djv279" target="_blank" >http://dx.doi.org/10.1093/jnci/djv279</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/jnci/djv279" target="_blank" >10.1093/jnci/djv279</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

  • Original language description

    Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

  • ISSN

    0027-8874

  • e-ISSN

  • Volume of the periodical

    107

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    1-11

  • UT code for WoS article

    000366970900015

  • EID of the result in the Scopus database