Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00087060" target="_blank" >RIV/00216224:14110/15:00087060 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/jnci/djv279" target="_blank" >http://dx.doi.org/10.1093/jnci/djv279</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jnci/djv279" target="_blank" >10.1093/jnci/djv279</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
Original language description
Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
ISSN
0027-8874
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000366970900015
EID of the result in the Scopus database
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