The viability of ovarian carcinoma cells A2780 affected by titanium dioxide nanoparticles and low ultrasound intensity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088253" target="_blank" >RIV/00216224:14110/16:00088253 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The viability of ovarian carcinoma cells A2780 affected by titanium dioxide nanoparticles and low ultrasound intensity
Original language description
The effect of titanium dioxide nanoparticles and ultrasound was studied on human ovarian carcinoma cells A2780 in vitro. The viability of cells has been studied by a standard 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide viability assay in different modes of treatment: application of nanoparticles alone, exposure to ultrasound field alone, application of nanoparticles followed by an exposure to ultrasound, and an exposure to ultrasound followed by addition of nanoparticles. The viability was measured 48 and 72 hours after the exposure. The titanium dioxide nanoparticles used were smaller than 100 nm in diameter, ultrasound was applied at a therapeutical intensity of 1 Wcm-2 and frequency of 1 MHz; the cells were treated in a 37 °C thermostated water bath in a configuration with far field ultrasound exposure. The final concentration of titanium dioxide nanoparticles was 50 microg/mL.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
<a href="/en/project/GP13-04408P" target="_blank" >GP13-04408P: Effects of combined nanoparticle and ultrasound treatment on carcinoma cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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