Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088860" target="_blank" >RIV/00216224:14110/16:00088860 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/16:00065617
Result on the web
<a href="http://dx.doi.org/10.1007/s10719-016-9688-9" target="_blank" >http://dx.doi.org/10.1007/s10719-016-9688-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10719-016-9688-9" target="_blank" >10.1007/s10719-016-9688-9</a>
Alternative languages
Result language
angličtina
Original language name
Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes
Original language description
While the pathogenic role of dicarbonyl stress and accelerated formation of advanced glycation end products (AGEs) to glucose intolerance and to the development of diabetic complications is well established, little is known about these processes in gestational diabetes mellitus (GDM), a condition pathogenically quite similar to type 2 diabetes. The aims of the present study were (i) to determine plasma thiamine and erythrocyte thiamine diphosphate (TDP) and transketolase (TKT) activity in pregnant women with and without GDM, (ii) to assess relationships between thiamine metabolism parameters and selected clinical, biochemical and anthropometric characteristics and, finally, (iii) to analyse relationship between variability in the genes involved in the regulation of transmembrane thiamine transport (i.e. SLC19A2 and SLC19A3) and relevant parameters of thiamine metabolism. We found significantly lower plasma BMI adjusted thiamine in women with GDM (P = 0.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13198" target="_blank" >NT13198: Pentose phosphate pathway as a potentially new therapeutic target in prevention of diabetic complications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Glycoconjugate Journal
ISSN
0282-0080
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
591-598
UT code for WoS article
000381157600011
EID of the result in the Scopus database
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