Plasma short-chain fatty acids and their derivatives in women with gestational diabetes mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73610219" target="_blank" >RIV/61989592:15110/21:73610219 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/21:N0000164

Result on the web

<a href="https://www.mdpi.com/2297-8739/8/10/188" target="_blank" >https://www.mdpi.com/2297-8739/8/10/188</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/separations8100188" target="_blank" >10.3390/separations8100188</a>

Result language

angličtina

Original language name

Plasma short-chain fatty acids and their derivatives in women with gestational diabetes mellitus

Original language description

Gestational diabetes mellitus (GDM) represents a heterogeneous group of hyperglycemic metabolic disorders that are associated with health outcomes for mothers and offspring. Currently, diagnosis of GDM is based on repetitive measurement of increased fasting plasma glucose (FPG) or upon results showing increased postprandial plasma glucose (PPG). Recently, it was discovered that the changes in the gut microbiome during pregnancy are associated with insulin resistance and obesity. Therefore, in this study, relevant products of gut bacteria, short-chain fatty acids (SCFA) and their derivatives were evaluated together with baseline body composition characteristics and common biochemical parameters in women with three different phenotypes of GDM, healthy pregnant and nonpregnant women. Plasma SCFA and their derivatives were derivatized, separated on reversed-phase liquid chromatography and detected by a triple-quadrupole mass spectrometer. 3-hydroxybutyrate (3-OH-BA), 4-methylvalerate (4-MVA) and isovalerate (IVA), together with selected parameters associated with baseline body composition characteristics and biochemistry, were evaluated as statistically significant. 3-OH-BA, which was increased in all three groups of women with different phenotypes of GDM, reflects a ketogenic state of GDM. In all groups of pregnant women, elevated/suppressed concentrations of 4-MVA/IVA were found. These findings show the importance of monitoring SCFA and other parameters besides glucose in women with GDM.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/NV18-01-00139" target="_blank" >NV18-01-00139: Gestational diabetes mellitus - contribution of entero-insular axis hormones, selected adipokines and gut microbiota to its different phenotypes</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Separations

ISSN

2297-8739

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

"nestránkováno"

UT code for WoS article

000716061600001

EID of the result in the Scopus database

2-s2.0-85118133366