Analysis of gamma-delta T cells and plasmacytoid dendritic cells in MGUS and Multiple Myeloma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088873" target="_blank" >RIV/00216224:14110/16:00088873 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/16:00065441
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Analysis of gamma-delta T cells and plasmacytoid dendritic cells in MGUS and Multiple Myeloma patients
Original language description
Multiple Myeloma (MM) remains incurable B-cell malignancy despite novel therapies. Plasmacytoid dendritic cells (pDC) have been shown to mediate tumour plasma cell growth, survival and drug resistance in MM patients. The role of effector gammadelta T cell interactions with pDC in patients progressing from monoclonal gammopathy of undetermined significance (MGUS) to MM is unknown. Our aim was to determine frequencies and phenotypes of pDC together with Vdelta1 and Vdelta2 gammadelta T cells. We used bone marrow (BM) and paired peripheral blood (PB) samples from MGUS (n=8) and newly diagnosed myeloma (n=11) patients. Total of n=24 age-matched healthy donors samples have been analysed. PDCs were analysed by multicolour flow cytometry as CD123+, CD303+, and CD304+. Phenotype of active pDC was identified as HLA-DR+ CD45RA+. In MGUS and MM patients, the medians of Vdelta1 T cells were comparable to normal levels in contrast to Vdelta2 T cells being significantly decreased in both patient cohorts.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-32935A" target="_blank" >NV15-32935A: Analysis of tumour-reactive gamma/delta T cells in patients with B-cell chronic lymphocytic leukaemia: a new approach to the cellular therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů