Long non-coding RNAs in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088895" target="_blank" >RIV/00216224:14110/16:00088895 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/16:00065614
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Long non-coding RNAs in multiple myeloma
Original language description
Introduction Multiple myeloma (MM) is the second most common hematological malignancy in the world. It is characterized by increasing rate of various genetic mutations and dysregulated pathways. This work aims to find out if this observed dysregulation may be al least partly caused by a subgroup of non-coding RNAs, so-called long non-coding RNA molecules (lncRNA). These molecules are over 200 nt long, primarily localized in the nucleus, and it seems increasingly obvious that lncRNAs play a role in variety of cell processes, such as proliferation, differentiation and apoptosis. Also, it seems that these lncRNAs have a crucial role in the pathogenesis of a wide range of human diseases, including cancer. Therefore, it is very likely they contribute to tumor transformation and disease progression in MM.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-29508A" target="_blank" >NV15-29508A: Circulating nucleic acids as markers of multiple myeloma progression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů