Cannabinoids and Cytochrome P450 Interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00089686" target="_blank" >RIV/00216224:14110/16:00089686 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/1389200217666151210142051" target="_blank" >http://dx.doi.org/10.2174/1389200217666151210142051</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389200217666151210142051" target="_blank" >10.2174/1389200217666151210142051</a>
Alternative languages
Result language
angličtina
Original language name
Cannabinoids and Cytochrome P450 Interactions
Original language description
Objective: This review consists of three parts, representing three different possibilities of interactions between cannabinoid receptor ligands of both exogenous and endogenous origin and cytochrome P450 enzymes (CYPs). The first part deals with cannabinoids as CYP substrates, the second summarizes current knowledge on the influence of various cannabinoids on the metabolic activity of CYP, and the third outline a possible involvement of the endocannabinoid system and cannabinoid ligands in the regulation of CYP liver activity. Methods: We performed a structured search of bibliographic and drug databases for peer-reviewed literature using focused review questions. Results: Biotransformation via a hydrolytic pathway is the major route of endocannabinoid metabolism and the deactivation of substrates is characteristic, in contrast to the minor oxidative pathway via CYP involved in the bioactivation reactions. Phytocannabinoids are extensively metabolized by CYPs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Drug Metabolism
ISSN
1389-2002
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
21
Pages from-to
206-226
UT code for WoS article
000373121600001
EID of the result in the Scopus database
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