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Cannabinoids and Cytochrome P450 Interactions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00089686" target="_blank" >RIV/00216224:14110/16:00089686 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.2174/1389200217666151210142051" target="_blank" >http://dx.doi.org/10.2174/1389200217666151210142051</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1389200217666151210142051" target="_blank" >10.2174/1389200217666151210142051</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cannabinoids and Cytochrome P450 Interactions

  • Original language description

    Objective: This review consists of three parts, representing three different possibilities of interactions between cannabinoid receptor ligands of both exogenous and endogenous origin and cytochrome P450 enzymes (CYPs). The first part deals with cannabinoids as CYP substrates, the second summarizes current knowledge on the influence of various cannabinoids on the metabolic activity of CYP, and the third outline a possible involvement of the endocannabinoid system and cannabinoid ligands in the regulation of CYP liver activity. Methods: We performed a structured search of bibliographic and drug databases for peer-reviewed literature using focused review questions. Results: Biotransformation via a hydrolytic pathway is the major route of endocannabinoid metabolism and the deactivation of substrates is characteristic, in contrast to the minor oxidative pathway via CYP involved in the bioactivation reactions. Phytocannabinoids are extensively metabolized by CYPs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Drug Metabolism

  • ISSN

    1389-2002

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    21

  • Pages from-to

    206-226

  • UT code for WoS article

    000373121600001

  • EID of the result in the Scopus database