Deregulated expression of long non-coding RNA UCA1 in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00095660" target="_blank" >RIV/00216224:14110/17:00095660 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/17:00067159 RIV/00843989:_____/17:E0106497
Result on the web
<a href="http://dx.doi.org/10.1111/ejh.12908" target="_blank" >http://dx.doi.org/10.1111/ejh.12908</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12908" target="_blank" >10.1111/ejh.12908</a>
Alternative languages
Result language
angličtina
Original language name
Deregulated expression of long non-coding RNA UCA1 in multiple myeloma
Original language description
ObjectivesLong non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that are not translated into proteins. They are involved in pathogenesis of many diseases including cancer and have a potential to serve as diagnostic and prognostic markers. We aimed to investigate lncRNA expression profiles in bone marrow plasma cells (BMPCs) of newly diagnosed multiple myeloma (MM) patients in comparison to normal BMPCs of healthy donors (HD) in a three-phase biomarker study. MethodsExpression profile of 83 lncRNA was performed by RT2 lncRNA PCR Array (Qiagen), followed by quantitative real-time PCR using specific TaqMan non-coding RNA assays analyzing 84 newly diagnosed MM patients and 25 HD. ResultsOur analysis revealed dysregulation of two lncRNAs; NEAT1 (sensitivity of 55.0% and specificity of 79.0%) and UCA1 (sensitivity of 85.0% and specificity of 94.7%). UCA1 levels correlated with albumin and monoclonal immunoglobulin serum levels, cytogenetic aberrations, and survival of MM patients. ConclusionOur study suggests a possible prognostic impact of UCA1 expression levels on MM patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV15-29508A" target="_blank" >NV15-29508A: Circulating nucleic acids as markers of multiple myeloma progression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Haematology
ISSN
0902-4441
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
223-233
UT code for WoS article
000408148200004
EID of the result in the Scopus database
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