Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00095669" target="_blank" >RIV/00216224:14110/17:00095669 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/17:00067263

Result on the web

<a href="http://dx.doi.org/10.1002/brb3.797" target="_blank" >http://dx.doi.org/10.1002/brb3.797</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/brb3.797" target="_blank" >10.1002/brb3.797</a>

Result language

angličtina

Original language name

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Original language description

Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NT13449" target="_blank" >NT13449: Spondylotic cervical cord compression, its prevalence, diagnosis and prognosis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain and Behavior

ISSN

2162-3279

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1-10

UT code for WoS article

000411368500027

EID of the result in the Scopus database

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