Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076107" target="_blank" >RIV/65269705:_____/22:00076107 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/22:00129737

Result on the web

<a href="https://journals.sagepub.com/doi/10.1177/21925682211036071" target="_blank" >https://journals.sagepub.com/doi/10.1177/21925682211036071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/21925682211036071" target="_blank" >10.1177/21925682211036071</a>

Result language

angličtina

Original language name

Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2]

Original language description

Study Design: Narrative review. Objectives: To discuss the current understanding of the natural history of degenerative cervical myelopathy (DCM). Methods: Literature review summarizing current evidence pertaining to the natural history and risk factors of DCM. Results: DCM is a common condition in which progressive arthritic disease of the cervical spine leads to spinal cord compression resulting in a constellation of neurological symptoms, in particular upper extremity dysfunction and gait impairment. Anatomical factors including cord-canal mismatch, congenitally fused vertebrae and genetic factors may increase individuals&apos; risk for DCM development. Non-myelopathic spinal cord compression (NMSCC) is a common phenomenon with a prevalence of 24.2% in the healthy population, and 35.3% among individuals &gt;60 years of age. Clinical radiculopathy and/or electrophysiological signs of cervical cord dysfunction appear to be risk factors for myelopathy development. Radiological progression of incidental Ossification of the Posterior Longitudinal Ligament (OPLL) is estimated at 18.3% over 81-months and development of myelopathy ranges between 0-61.5% (follow-up ranging from 40 to 124 months between studies) among studies. In patients with symptomatic DCM undergoing non-operative treatment, 20-62% will experience neurological deterioration within 3-6 years. Conclusion: Current estimates surrounding the natural history of DCM, particularly those individuals with mild or minimal impairment, lack precision. Clear predictors of clinical deterioration for those treated with non-operative care are yet to be identified. Future studies are needed on this topic to help improve treatment counseling and clinical prognostication.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV18-04-00159" target="_blank" >NV18-04-00159: Advanced magnetic resonance techniques to disclose pathophysiology and improve diagnosis and clinical management of degenerative cervical cord compression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Global Spine Journal

ISSN

2192-5682

e-ISSN

2192-5690

Volume of the periodical

12

Issue of the periodical within the volume

1_Suppl

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

"39S"-"54S"

UT code for WoS article

000758327200005

EID of the result in the Scopus database

2-s2.0-85125776865