Progress in human pluripotent stem cell-based modeling systems for neurological diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098812" target="_blank" >RIV/00216224:14110/17:00098812 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1080/23262133.2017.1324258" target="_blank" >http://dx.doi.org/10.1080/23262133.2017.1324258</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/23262133.2017.1324258" target="_blank" >10.1080/23262133.2017.1324258</a>

Result language

angličtina

Original language name

Progress in human pluripotent stem cell-based modeling systems for neurological diseases

Original language description

Human pluripotent stem cell (hPSC)-based modeling offers the potential for studying human diseases using human systems. An increasing number of studies in numerous fields demonstrate that hPSC-based disease systems capture disease specific pathophysiology occurring in vivo. A widespread deployment of hPSC systems is foreseeable. Even the field of psychiatric disorders (for example, schizophrenia and autism), which lags behind due to complex underlying causes, such as the inaccessibility of brain cells for assessments and the absence of reliable models, has been embracing the hPSC-based disease system. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. Our recent study demonstrated that the hPSC-based system mimicked the process of neural development and the system reserved neural stem cell (NSC) niches similar to those residing in the ventricular region of the cortex. In this article, we will first comment on an array of factors that affect hPSC-based neural differentiation and summarize the intricate regulatory signaling pathways that regionalize neuronal cell types. Finally, we review successful studies in brain-related diseases using hPSC-based modeling with 3-D systems.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurogenesis

ISSN

2326-2133

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

„e1324258-1“-„e1324258-6“

UT code for WoS article

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EID of the result in the Scopus database

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