Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00100920" target="_blank" >RIV/00216224:14110/18:00100920 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10376687 RIV/00159816:_____/18:00068580 RIV/00064165:_____/18:10376687

Result on the web

<a href="http://dx.doi.org/10.1111/jop.12694" target="_blank" >http://dx.doi.org/10.1111/jop.12694</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jop.12694" target="_blank" >10.1111/jop.12694</a>

Result language

angličtina

Original language name

Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

Original language description

Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr &lt; .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Oral Pathology & Medicine

ISSN

0904-2512

e-ISSN

1600-0714

Volume of the periodical

47

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

434-439

UT code for WoS article

000430125800016

EID of the result in the Scopus database

2-s2.0-85042632552