Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00101375" target="_blank" >RIV/00216224:14110/18:00101375 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10382980 RIV/00159816:_____/18:00069068 RIV/00064165:_____/18:10382980

Result on the web

<a href="http://dx.doi.org/10.1111/eos.12577" target="_blank" >http://dx.doi.org/10.1111/eos.12577</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/eos.12577" target="_blank" >10.1111/eos.12577</a>

Result language

angličtina

Original language name

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

Original language description

Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor alpha, IL4R alpha), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4R alpha, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EUROPEAN JOURNAL OF ORAL SCIENCES

ISSN

0909-8836

e-ISSN

1600-0722

Volume of the periodical

126

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

485-492

UT code for WoS article

000449881600006

EID of the result in the Scopus database

2-s2.0-85055273192