SAMHD1 acts at stalled replication forks to prevent interferon induction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00101770" target="_blank" >RIV/00216224:14110/18:00101770 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/18:00068684
Result on the web
<a href="http://dx.doi.org/10.1038/s41586-018-0050-1" target="_blank" >http://dx.doi.org/10.1038/s41586-018-0050-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41586-018-0050-1" target="_blank" >10.1038/s41586-018-0050-1</a>
Alternative languages
Result language
angličtina
Original language name
SAMHD1 acts at stalled replication forks to prevent interferon induction
Original language description
SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections. Mutations in SAMHD1 are implicated in cancer development and in a severe congenital inflammatory disease known as Aicardi-Goutieres syndrome. The mechanism by which SAMHD1 protects against cancer and chronic inflammation is unknown. Here we show that SAMHD1 promotes degradation of nascent DNA at stalled replication forks in human cell lines by stimulating the exonuclease activity of MRE11. This function activates the ATR-CHK1 checkpoint and allows the forks to restart replication. In SAMHD1-depleted cells, single-stranded DNA fragments are released from stalled forks and accumulate in the cytosol, where they activate the cGAS-STING pathway to induce expression of pro-inflammatory type I interferons. SAMHD1 is thus an important player in the replication stress response, which prevents chronic inflammation by limiting the release of single-stranded DNA from stalled replication forks.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
1476-4687
Volume of the periodical
557
Issue of the periodical within the volume
7703
Country of publishing house
GB - UNITED KINGDOM
Number of pages
26
Pages from-to
„57“-„+“
UT code for WoS article
000431234500029
EID of the result in the Scopus database
2-s2.0-85046344158