All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Inward rectifying potassium currents resolved into components: modeling of complex drug actions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00106922" target="_blank" >RIV/00216224:14110/18:00106922 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00424-017-2071-2" target="_blank" >http://dx.doi.org/10.1007/s00424-017-2071-2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00424-017-2071-2" target="_blank" >10.1007/s00424-017-2071-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inward rectifying potassium currents resolved into components: modeling of complex drug actions

  • Original language description

    Inward rectifier potassium currents (I (Kir,x)) belong to prominent ionic currents affecting both resting membrane voltage and action potential repolarization in cardiomyocytes. In existing integrative models of electrical activity of cardiac cells, they have been described as single current components. The proposed quantitative model complies with findings indicating that these channels are formed by various homomeric or heteromeric assemblies of channel subunits with specific functional properties. Each I (Kir,x) may be expressed as a total of independent currents via individual populations of identical channels, i.e., channels formed by the same combination of their subunits. Solution of the model equations simulated well recently observed unique manifestations of dual ethanol effect in rat ventricular and atrial cells. The model reflects reported occurrence of at least two binding sites for ethanol within I (Kir,x) channels related to slow allosteric conformation changes governing channel conductance and inducing current activation or inhibition. Our new model may considerably improve the existing models of cardiac cells by including the model equations proposed here in the particular case of the voltage-independent drug-channel interaction. Such improved integrative models may provide more precise and, thus, more physiologically relevant results.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    <a href="/en/project/NV16-30571A" target="_blank" >NV16-30571A: Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926C>T (p.T309I) as a possible long QT syndrome founder mutation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

  • ISSN

    0031-6768

  • e-ISSN

    1432-2013

  • Volume of the periodical

    470

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    315-325

  • UT code for WoS article

    000423161400010

  • EID of the result in the Scopus database

    2-s2.0-85029798851