Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00106957" target="_blank" >RIV/00216224:14110/18:00106957 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/ijms19113696" target="_blank" >http://dx.doi.org/10.3390/ijms19113696</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19113696" target="_blank" >10.3390/ijms19113696</a>

Result language

angličtina

Original language name

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

Original language description

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/NV16-28040A" target="_blank" >NV16-28040A: Long-term consequences of gestational diabetes for metabolic health of exposed women early postpartum: significance of the new diagnostic cri</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1-13

UT code for WoS article

000451528500411

EID of the result in the Scopus database

2-s2.0-85057109078