Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108019" target="_blank" >RIV/00216224:14110/19:00108019 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/infdis/jiy604" target="_blank" >http://dx.doi.org/10.1093/infdis/jiy604</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/infdis/jiy604" target="_blank" >10.1093/infdis/jiy604</a>
Alternative languages
Result language
angličtina
Original language name
Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017
Original language description
Background. The increased prevalence of syphilis in Cuba prompted us to map the circulating Treponema pallidum subsp. pallidum allelic profiles in this geographic region. Methods. Samples were collected from 2012 to 2017, from 83 male patients with ulcers or skin lesions, and were examined using multilocus sequence typing. Additionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible mutations leading to macrolide and tetracycline resistance. Results. Among 94% of fully typed strains, we found 7 different allelic profiles, of which 4 had not been previously described. More than 87% of patients were infected with the T. pallidum SS14-like group and only 8.2% with T. pallidum Nichols-like group. As in other countries, the 1.3.1 allelic profile (ie, SS14-like) was the most common. In addition, 1 of the newly described allelic profiles represents T. pallidum strains that arose by recombination events between members of different T. pallidum subgroups. More than 90% of patients were infected with treponemes harboring the A2058G mutation. However, we found no potential tetracycline-resistant T. pallidum mutations. Conclusions. Our results suggest that, in Cuba, tetracycline antibiotics could be used to treat syphilis in penicillin-allergic patients instead of macrolides.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Infectious Diseases
ISSN
0022-1899
e-ISSN
1537-6613
Volume of the periodical
219
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1138-1145
UT code for WoS article
000472805600016
EID of the result in the Scopus database
2-s2.0-85063001157