Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00118622" target="_blank" >RIV/00216224:14110/20:00118622 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx" target="_blank" >https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/OLQ.0000000000001217" target="_blank" >10.1097/OLQ.0000000000001217</a>
Alternative languages
Result language
angličtina
Original language name
Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients
Original language description
Objectives This study aimed to determine the allelic profiles ofTreponema pallidumin patients confirmed with syphilis in Cuba (2018-2019) and to explore mutations leading to macrolide and tetracycline resistance. Methods Multilocus sequence typing and polymerase chain reaction ofrrnloci (23S and 16S rDNA), followed by Sanger sequencing, were used to define the allelic profile of TPA and resistance mutations, respectively. Results Allelic profile 1.3.1 and the recombinant profile were identified, with 15.7.3 having an increased frequency. We did not detect the presence of theT. pallidumsubspeciesendemicumamong syphilis patients, as in previous reports. A high frequency of macrolide-resistant strains and the absence of mutations potentially causing tetracycline resistance were found. Conclusions Understanding the current status of treponemal infection in Cuban patients provides insights into the syphilis epidemiology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/NV17-31333A" target="_blank" >NV17-31333A: Development of a new typing scheme for syphilis spirochete, Treponema pallidum subsp. pallidum, preferentially targeting proteome differences</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sexually transmitted diseases
ISSN
0148-5717
e-ISSN
1537-4521
Volume of the periodical
47
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
„E39“-„E41“
UT code for WoS article
000574642100001
EID of the result in the Scopus database
2-s2.0-85091126765