The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108461" target="_blank" >RIV/00216224:14110/19:00108461 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/19:00070888
Result on the web
<a href="http://dx.doi.org/10.1016/j.blre.2018.11.003" target="_blank" >http://dx.doi.org/10.1016/j.blre.2018.11.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.blre.2018.11.003" target="_blank" >10.1016/j.blre.2018.11.003</a>

Result language
angličtina
Original language name
The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma
Original language description
Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/NV15-29508A" target="_blank" >NV15-29508A: Circulating nucleic acids as markers of multiple myeloma progression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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