Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108573" target="_blank" >RIV/00216224:14110/19:00108573 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/19:00071470

Result on the web

<a href="http://dx.doi.org/10.1007/s00330-019-06268-8" target="_blank" >http://dx.doi.org/10.1007/s00330-019-06268-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00330-019-06268-8" target="_blank" >10.1007/s00330-019-06268-8</a>

Result language

angličtina

Original language name

Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults

Original language description

Objectives Although white matter hyperintensities (WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity. Methods MRI brain scan using multimodal protocol was performed in 60 neurologically asymptomatic volunteers (21 men, 39 women, mean age 34.5 years). WMHs were manually segmented in 3D FLAIR images and counted automatically. The number and volume of WMHs were correlated with brain volume, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data. Diffusion parameters measured within WMHs and normally appearing white matter (NAWM) were compared. Results At least 1 lesion was found in 40 (67%) subjects, median incidence was 1 lesion (interquartile range [IQR]=4.5), and median volume was 86.82 (IQR=227.23) mm(3). Neither number nor volume of WMHs correlated significantly with total brain volume or volumes of white and grey matter. Mean diffusivity values within WMHs were significantly higher compared with those for NAWM, but none of the diffusion parameters of NAWM were significantly correlated with WMH load. Both the number and volume of WMHs were correlated with the changes of functional connectivity between several regions of the brain, mostly decreased connectivity of the cerebellum. Conclusions WMHs are commonly found even in young, neurologically asymptomatic adults. Their presence is not associated with brain atrophy or global changes of diffusivity, but the increasing number and volume of these lesions correlate with changes of brain connectivity, and especially that of the cerebellum.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NV15-32133A" target="_blank" >NV15-32133A: Predicting conversion of clinically isolated syndrome to multiple sclerosis using advanced magnetic resonance imaging techniques</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Radiology

ISSN

0938-7994

e-ISSN

1432-1084

Volume of the periodical

29

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

7027-7036

UT code for WoS article

000500979400066

EID of the result in the Scopus database

2-s2.0-85071324533