Poor outcome in hypoxic endometrial carcinoma is related to vascular density
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00112513" target="_blank" >RIV/00216224:14110/19:00112513 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/s41416-019-0461-2" target="_blank" >http://dx.doi.org/10.1038/s41416-019-0461-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41416-019-0461-2" target="_blank" >10.1038/s41416-019-0461-2</a>
Alternative languages
Result language
angličtina
Original language name
Poor outcome in hypoxic endometrial carcinoma is related to vascular density
Original language description
BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British journal of cancer
ISSN
0007-0920
e-ISSN
1532-1827
Volume of the periodical
120
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1037-1044
UT code for WoS article
000469218100004
EID of the result in the Scopus database
2-s2.0-85064761908