Biphasic calcium phosphate scaffolds with controlled pore size distribution prepared by in-situ foaming

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00112788" target="_blank" >RIV/00216224:14110/19:00112788 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/19:PU130116

Result on the web

<a href="http://dx.doi.org/10.1016/j.msec.2018.03.022" target="_blank" >http://dx.doi.org/10.1016/j.msec.2018.03.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2018.03.022" target="_blank" >10.1016/j.msec.2018.03.022</a>

Result language

angličtina

Original language name

Biphasic calcium phosphate scaffolds with controlled pore size distribution prepared by in-situ foaming

Original language description

In this study, a reproducible method of fabricating hierarchically 3D porous scaffolds with high porosity and pore interconnectivity is reported. The method is based on in-situ foaming of a dispersion of diisocyanate, polyol, water and hydroxyapatite (HA) to form a hard foamed HA/polyurethane composite which after heat treatment provided a bi-phase calcium phosphate scaffold. This technique, combining the advantages of polymer sponge and direct foaming methods, provides a better control over the macrostructure of the scaffold. A modification of the multi-scaled porous macrostructure of scaffolds produced by changing the ratio of input reactants and by sintering temperature was studied. The pore morphology, size, and distribution were characterized using a scanning electron microscope and mercury porosimetry. The pores were open and interconnected with multi-scale (from several nanometres to millimetres) sizes convenient for using in tissue engineering applications. The bioactivity was confirmed by growing an apatite layer on the surfaces after immersion in simulated body fluid. The material was biocompatible, as shown by using normal human adipose tissue-derived stem cells (ASC). When seeded onto the scaffolds, the ASC adhered and remained healthy while maintaining their typical morphology.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MATERIALS SCIENCE &amp; ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

ISSN

0928-4931

e-ISSN

1873-0191

Volume of the periodical

95

Issue of the periodical within the volume

FEB 1 2019

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

363-370

UT code for WoS article

000455858300039

EID of the result in the Scopus database

2-s2.0-85046124544