Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00120125" target="_blank" >RIV/00216224:14110/19:00120125 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00125-019-4946-6" target="_blank" >https://link.springer.com/article/10.1007/s00125-019-4946-6</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease

Original language description

Diabetic kidney disease (DKD) is one of the most serious complications of type 2 diabetes mellitus (T2DM). Individual predisposition to development and progression of DKD has well established genetic component however it is still insufficiently explored. Genetic predisposition to T2DM is comprehensively described and genetic risk score (GRS) composed of 65 SNPs that is associated with 3-times higher risk of T2DM development has been established. In our study we tested the hypothesis that reduced GRS (comprised of 21 SNP with highest OR) might represent a risk factor for DKD progression and cardiovascular morbidity and mortality in T2DM patients in the Czech population.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetic score in prediction of diabetes and its complications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů