Relationship between genetic risk score for kidney function and diabetic kidney disease progression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00120129" target="_blank" >RIV/00216224:14110/20:00120129 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00125-020-05221-5" target="_blank" >https://link.springer.com/article/10.1007/s00125-020-05221-5</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relationship between genetic risk score for kidney function and diabetic kidney disease progression

Original language description

Background and aims: Diabetic kidney disease (DKD) is a serious diabetic complication. Several risk factors contribute to the DKD development or progression (e.g. glucose control, hypertension, dyslipidaemia). Genetic predisposition also contributes to the total risk however it is still insufficiently explored. Recently, several genome-wide association studies (GWAS) identified a number of single nucleotide polymorphisms (SNP) associated with kidney function. We selected 9 SNPs and constructed a genetic risk score (GRS). The aim of the work was to find out whether GRS can predict the progression of DKD or cardiovascular morbidity and mortality in patients with T2DM in the Czech population.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetic score in prediction of diabetes and its complications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů