KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00114130" target="_blank" >RIV/00216224:14110/20:00114130 - isvavai.cz</a>
Result on the web
<a href="https://rupress.org/jcb/article/219/6/e201904107/151721/KIF14-controls-ciliogenesis-via-regulation-of?searchresult=1" target="_blank" >https://rupress.org/jcb/article/219/6/e201904107/151721/KIF14-controls-ciliogenesis-via-regulation-of?searchresult=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1083/jcb.201904107" target="_blank" >10.1083/jcb.201904107</a>

Result language
angličtina
Original language name
KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling
Original language description
Primary cilia play critical roles in development and disease. Their assembly and disassembly are tightly coupled to cell cycle progression. Here, we present data identifying KIF14 as a regulator of cilia formation and Hedgehog (HH) signaling. We show that RNAi depletion of KIF14 specifically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the distal appendage proteins SCLT1 and FBF1 and components of the IFT-B complex. We identify deregulated Aurora A activity as a mechanism contributing to the primary cilium and BB formation defects seen after KIF14 depletion. In addition, we show that primary cilia in KIF14-depleted cells are defective in response to HH pathway activation, independently of the effects of Aurora A. In sum, our data point to KIF14 as a critical node connecting cell cycle machinery, effective ciliogenesis, and HH signaling.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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