High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00114768" target="_blank" >RIV/00216224:14110/20:00114768 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbed.13551" target="_blank" >https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbed.13551</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tbed.13551" target="_blank" >10.1111/tbed.13551</a>
Alternative languages
Result language
angličtina
Original language name
High syphilis seropositivity in European brown hares (Lepus europaeus), Lower Saxony, Germany
Original language description
The lagomorph-infecting Treponema paraluisleporidarum is a close relative of the human syphilis-bacterium Treponema pallidum. There is a paucity of information on the epidemiology of hare syphilis and its relationship to the rabbit- and human-infecting treponemes that cause syphilis. In our study, we tested 734 serum samples from European brown hares (Lepus europaeus) collected between 2007 and 2019 in the federal state of Lower Saxony, Germany, for the presence of antibodies against T. paraluisleporidarum. Since T. paraluisleporidarum cross-reacts with T. pallidum antigen, we used a commercially available T. pallidum-particle agglutination (TP-PA) assay to test for the presence of antibodies. A high seropositivity (n = 405/734) was detected. An additional 233 serum samples were retested using a fluorescent treponemal antibody absorption test to confirm the results of the TP-PA assay. Our results show that infection is widespread in Lower Saxony and suggest a horizontal (sexual) transmission mode since adult hares show significantly higher seropositivity than subadults (odds ratio: 0.03 [95% CI 0.02-0.05], p < .0001). No difference was detected based on gender (odds ratio: 0.79 [95% Cl 0.58-1.07], p = .1283). Further studies are warranted to genetically characterize the T. paraluisleporidarum strains that infect wild hares.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/GC18-23521J" target="_blank" >GC18-23521J: Treponemes in wild lagomorphs: Genetic diversity and relatedness to human pathogenic T. pallidum</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transboundary and Emerging Diseases
ISSN
1865-1674
e-ISSN
1865-1682
Volume of the periodical
67
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
2240-2244
UT code for WoS article
000524336300001
EID of the result in the Scopus database
2-s2.0-85082930280