Non-coding RNAs and Cardiac Arrhythmias
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115272" target="_blank" >RIV/00216224:14110/20:00115272 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17" target="_blank" >https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-981-15-1671-9_17" target="_blank" >10.1007/978-981-15-1671-9_17</a>
Alternative languages
Result language
angličtina
Original language name
Non-coding RNAs and Cardiac Arrhythmias
Original language description
Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advances in Experimental Medicine and Biology
ISSN
0065-2598
e-ISSN
2214-8019
Volume of the periodical
1229
Issue of the periodical within the volume
2020
Country of publishing house
SG - SINGAPORE
Number of pages
14
Pages from-to
287-300
UT code for WoS article
000539026500017
EID of the result in the Scopus database
2-s2.0-85083378686