Effect of helical kink in antimicrobial peptides on membrane pore formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00523363" target="_blank" >RIV/61388955:_____/20:00523363 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/20:00114711
Result on the web
<a href="http://hdl.handle.net/11104/0307723" target="_blank" >http://hdl.handle.net/11104/0307723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.47946" target="_blank" >10.7554/eLife.47946</a>
Alternative languages
Result language
angličtina
Original language name
Effect of helical kink in antimicrobial peptides on membrane pore formation
Original language description
The cardiac ventricular action potential depends on several voltage-gated ion channels, including Nav, Cav, and Kv channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudden cardiac death. Polyunsaturated fatty acids (PUFAs) have emerged as potential therapeutics for LQTS because they are modulators of voltage-gated ion channels. Here we demonstrate that PUFA analogues vary in their selectivity for human voltage-gated ion channels involved in the ventricular action potential. The effects of specific PUFA analogues range from selective for a specific ion channel to broadly modulating cardiac ion channels from all three families (Nav, Cav, and KV). In addition, a PUFA analogue selective for the cardiac IKs channel (Kv7.1/KCNE1) is effective in shortening the cardiac action potential in human-induced pluripotent stem cell-derived cardiomyocytes. Our data suggest that PUFA analogues could potentially be developed as therapeutics for LQTS and cardiac arrhythmia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
—
Volume of the periodical
9
Issue of the periodical within the volume
FEB 2020
Country of publishing house
GB - UNITED KINGDOM
Number of pages
38
Pages from-to
47946
UT code for WoS article
000519949800001
EID of the result in the Scopus database
2-s2.0-85082096545