Severe hyperuricemia in two children with acute gastroenteritis: answers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115904" target="_blank" >RIV/00216224:14110/20:00115904 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/20:00073025
Result on the web
<a href="https://link.springer.com/article/10.1007/s00467-020-04493-8" target="_blank" >https://link.springer.com/article/10.1007/s00467-020-04493-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00467-020-04493-8" target="_blank" >10.1007/s00467-020-04493-8</a>

Result language
angličtina
Original language name
Severe hyperuricemia in two children with acute gastroenteritis: answers
Original language description
Uric acid (UA) is the end product of purine catabolism in humanoids, since the hepatocyte enzyme uricase, which degrades UA to allantoin in other mammals, is completely inactive. Approximately 65–75% of the UA produced daily is excreted by the kidneys, while the remaining 25–35% exits in the stool. Homeostasis of UA is determined by the balance between production and excretion. Hyperuricemia is caused by all conditions associated with increased purine synthesis and degradation during excessive cell breakdown and follow-up catabolism of nucleic acids, or an inability of the kidneys and gastrointestinal tract relative to urate excretion and clearance. During childhood, it is important to evaluate age- and sex-related serum UA concentration with respect to reference values.
Czech name
—
Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
30209 - Paediatrics

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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