Primary Mammary Organoid Model of Lactation and Involution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116164" target="_blank" >RIV/00216224:14110/20:00116164 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2020.00068" target="_blank" >10.3389/fcell.2020.00068</a>
Alternative languages
Result language
angličtina
Original language name
Primary Mammary Organoid Model of Lactation and Involution
Original language description
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
MAR 2020
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
1-13
UT code for WoS article
000525631100001
EID of the result in the Scopus database
2-s2.0-85086156648