Mechanisms and incidence of torsades de pointes tachycardia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00118093" target="_blank" >RIV/00216224:14110/20:00118093 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/20:00073372
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/B9780128177280000267" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780128177280000267</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7" target="_blank" >10.1016/B978-0-12-817728-0.00026-7</a>

Result language
angličtina
Original language name
Mechanisms and incidence of torsades de pointes tachycardia
Original language description
Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.
Czech name
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Czech description
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Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women
ISBN
9780128177280
Number of pages of the result
6
Pages from-to
303-308
Number of pages of the book
1032
Publisher name
Academic Press
Place of publication
Neuveden
UT code for WoS chapter
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