All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Intact Cell Mass Spectrometry for Embryonic Stem Cell Biotyping

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120903" target="_blank" >RIV/00216224:14110/21:00120903 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.intechopen.com/online-first/intact-cell-mass-spectrometry-for-embryonic-stem-cell-biotyping" target="_blank" >https://www.intechopen.com/online-first/intact-cell-mass-spectrometry-for-embryonic-stem-cell-biotyping</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5772/intechopen.95074" target="_blank" >10.5772/intechopen.95074</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Intact Cell Mass Spectrometry for Embryonic Stem Cell Biotyping

  • Original language description

    Stem cells represent a unique cell type that is capable of self-renewal and differentiation into somatic cell types. Since the derivation of human embryonic stem cells and induced pluripotent stem cells, enormous potential has been recognized for disease modeling, drug development and regenerative medicine. Both embryonic stem cells and induced pluripotent stem cells possess the ability to differentiate into all three germ layers, hence they are naturally prone to respond to various differentiation stimuli. These inherent cellular fluctuations, which can result in risky phenotypic instability, must be addressed prior to introduction of these cells to human medicine, since they represent one of the major biosafety obstacles in the development of bio-industrial or clinical-grade stem cell cultures. Therefore, there is an ongoing need for novel robust, feasible and sensitive methods for determination and confirmation of the otherwise identical cells status, as well as for the detection of hidden divergences from their optimal state. A method of choice can be the intact cell mass spectrometry. Here we show how it can be applied in routine quality control of embryonic stem cell cultures.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Mass Spectrometry in Life Sciences and Clinical Laboratory

  • ISBN

    9781838818623

  • Number of pages of the result

    19

  • Pages from-to

    133-151

  • Number of pages of the book

    152

  • Publisher name

    IntechOpen

  • Place of publication

    London

  • UT code for WoS chapter