Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00121956" target="_blank" >RIV/00216224:14110/21:00121956 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9" target="_blank" >https://www.frontiersin.org/articles/10.3389/fragi.2021.708788/full#h9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fragi.2021.708788" target="_blank" >10.3389/fragi.2021.708788</a>
Alternative languages
Result language
angličtina
Original language name
Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
Original language description
The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as “inflammaging.” Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Aging
ISSN
1663-4365
e-ISSN
1663-4365
Volume of the periodical
2021
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
1-20
UT code for WoS article
001090275600001
EID of the result in the Scopus database
2-s2.0-85140575678