Longitudinal evidence for immunosenescence and inflammaging in free-living great tits
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F21%3A00545282" target="_blank" >RIV/68081766:_____/21:00545282 - isvavai.cz</a>
Alternative codes found
RIV/00020699:_____/21:N0000124 RIV/00216208:11310/21:10430894 RIV/60460709:41330/21:87056
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exger.2021.111527" target="_blank" >10.1016/j.exger.2021.111527</a>
Alternative languages
Result language
angličtina
Original language name
Longitudinal evidence for immunosenescence and inflammaging in free-living great tits
Original language description
The first-line effector mechanisms of immune defence, including inflammation and oxidative burst, contribute significantly to host-pathogen resistance. Whether these immune responses undergo age-related changes in birds remains unknown. Here, we tracked selected inflammatory parameters in 54 free-living great tits (Parus major) of known age, captured repeatedly over three consecutive years, with the aims to investigate long-term repeatability and age-dependent changes in cellular oxidative burst responsiveness upon in vitro stimulation with bacterial lipopolysaccharide (LPS), and to identify its relationships with leukotriene B4 (LTB4) levels and haematological traits. In addition, we linked these immunological traits to selected physiological markers (antioxidants and oxidative stress markers). LTB4 levels increased with age and we have shown a similar non-significant tendency also for absolute granulocyte counts, indicating propagating chronic inflammation over the bird's lifetime, consistent with the inflammaging hypothesis. In contrast, cellular oxidative burst followed a quadratic trend of dependency on age with a peak in midlife individuals, in line with the immunosenescence hypothesis. Interestingly, LTB4 levels were positively associated with general oxidative damage, but negatively with antioxidant glutathione peroxidase activity, indicating links to redox balance. This longitudinal study demonstrates the contrasting patterns of age-related changes in background and acute markers of pro-inflammatory immunity contributing to immunosenescence in birds and thus provides basis for interpretation of the tested inflammatory markers in cross-cohort datasets.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10615 - Ornithology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Gerontology
ISSN
0531-5565
e-ISSN
1873-6815
Volume of the periodical
154
Issue of the periodical within the volume
October
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
111527
UT code for WoS article
000697723500007
EID of the result in the Scopus database
2-s2.0-85114095516