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Longitudinal evidence for immunosenescence and inflammaging in free-living great tits

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F21%3A00545282" target="_blank" >RIV/68081766:_____/21:00545282 - isvavai.cz</a>

  • Alternative codes found

    RIV/00020699:_____/21:N0000124 RIV/00216208:11310/21:10430894 RIV/60460709:41330/21:87056

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0531556521003090?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.exger.2021.111527" target="_blank" >10.1016/j.exger.2021.111527</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Longitudinal evidence for immunosenescence and inflammaging in free-living great tits

  • Original language description

    The first-line effector mechanisms of immune defence, including inflammation and oxidative burst, contribute significantly to host-pathogen resistance. Whether these immune responses undergo age-related changes in birds remains unknown. Here, we tracked selected inflammatory parameters in 54 free-living great tits (Parus major) of known age, captured repeatedly over three consecutive years, with the aims to investigate long-term repeatability and age-dependent changes in cellular oxidative burst responsiveness upon in vitro stimulation with bacterial lipopolysaccharide (LPS), and to identify its relationships with leukotriene B4 (LTB4) levels and haematological traits. In addition, we linked these immunological traits to selected physiological markers (antioxidants and oxidative stress markers). LTB4 levels increased with age and we have shown a similar non-significant tendency also for absolute granulocyte counts, indicating propagating chronic inflammation over the bird's lifetime, consistent with the inflammaging hypothesis. In contrast, cellular oxidative burst followed a quadratic trend of dependency on age with a peak in midlife individuals, in line with the immunosenescence hypothesis. Interestingly, LTB4 levels were positively associated with general oxidative damage, but negatively with antioxidant glutathione peroxidase activity, indicating links to redox balance. This longitudinal study demonstrates the contrasting patterns of age-related changes in background and acute markers of pro-inflammatory immunity contributing to immunosenescence in birds and thus provides basis for interpretation of the tested inflammatory markers in cross-cohort datasets.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10615 - Ornithology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental Gerontology

  • ISSN

    0531-5565

  • e-ISSN

    1873-6815

  • Volume of the periodical

    154

  • Issue of the periodical within the volume

    October

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    111527

  • UT code for WoS article

    000697723500007

  • EID of the result in the Scopus database

    2-s2.0-85114095516