Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067117" target="_blank" >RIV/00159816:_____/17:00067117 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00099687 RIV/65269705:_____/17:00067117

Result on the web

<a href="http://journal.frontiersin.org/article/10.3389/fimmu.2017.01078/abstract" target="_blank" >http://journal.frontiersin.org/article/10.3389/fimmu.2017.01078/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2017.01078" target="_blank" >10.3389/fimmu.2017.01078</a>

Result language

angličtina

Original language name

Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex?

Original language description

Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NFkB, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

SEP

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

1078

UT code for WoS article

000409062200001

EID of the result in the Scopus database

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