Telomerase-Positive Somatic Tissues of Honeybee Queens (Apis mellifera) Display No DNA Replication

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903651" target="_blank" >RIV/60076658:12310/21:43903651 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00549905
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/34649236/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/34649236/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000518888" target="_blank" >10.1159/000518888</a>

Result language
angličtina
Original language name
Telomerase-Positive Somatic Tissues of Honeybee Queens (Apis mellifera) Display No DNA Replication
Original language description
Telomere biology is closely linked to the process of aging. The restoration of telomere length by maintaining telome-rase activity in certain cell types of human adults allows for the proliferative capacity of the cells and preserves the regeneration potential of the tissue. The absence of telome-rase, that leads to telomere attrition and irreversible cell cycle arrest in most somatic cells, acts as a protective mechanism against uncontrolled cancer growth. Nevertheless, there have been numerous studies indicating noncanonical functions of telomerase besides those involved in telomere lengthening. Eusocial insects serve as a great system for aging research. This is because eusocial reproductives, such as queens and kings, have a significantly extended lifespan compared to nonreproductive individuals of the same species. We report that the somatic tissues of honeybee queens (Apis mellifera) are associated with upregulated telomerase activity; however, this upregulation does not fully correlate with the rate of DNA replication in the tissues. This indicates a noncanonical role of telomerase in the somatic tissues of honeybee queens. © 2021 S. Karger AG, Basel.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/GA18-21200S" target="_blank" >GA18-21200S: Mechanistic aspects of extended longevity of termite kings and queens</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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