Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00509046" target="_blank" >RIV/60077344:_____/19:00509046 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/19:43899784

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0965174819303558?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0965174819303558?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ibmb.2019.103241" target="_blank" >10.1016/j.ibmb.2019.103241</a>

Result language

angličtina

Original language name

Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris)

Original language description

The attrition of telomeres, the ends of eukaryote chromosomes, and activity of telomerase, the enzyme that restores telomere length, play a role in the ageing process and act as indicators of biological age. A notable feature of advanced eusocial insects is the longevity of reproductive individuals (queens and kings) compared to those from non-reproductive castes (workers and soldiers) within a given species, with a proposed link towards upregulation of telomerase activity in the somatic tissues of reproductive individuals. Given this, eusocial insects provide excellent model systems for research into ageing. We tested telomerase activity and measured telomere length in Bombus terrestris, which is a primitively eusocial insect species with several distinct features compared to advanced social insects. In somatic tissues, telomerase activity was upregulated only in the fat bodies of pre-diapause queens, and this upregulation was linked to heightened DNA synthesis. Telomere length was shorter in old queens compared to that in younger queens or workers. We speculate that (1) the upregulation of telomerase activity, together with DNA synthesis, is the essential step for intensifying metabolic activity in the fat body to build up a sufficient energy reserve prior to diapause, and that (2) the lifespan differences between B. terrestris workers and queens are related to the long diapause period of the queen. A possible relationship between telomere length regulation and TOR, FOXO, and InR as cell signaling components, was tested.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Insect Biochemistry and Molecular Biology

ISSN

0965-1748

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

DEC 01

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

103241

UT code for WoS article

000500048500002

EID of the result in the Scopus database

2-s2.0-85072401329