The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00127554" target="_blank" >RIV/00216224:14110/22:00127554 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/22:00078128 RIV/00159816:_____/22:00078128
Result on the web
<a href="https://www.nature.com/articles/s41588-022-01236-3" target="_blank" >https://www.nature.com/articles/s41588-022-01236-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41588-022-01236-3" target="_blank" >10.1038/s41588-022-01236-3</a>

Result language
angličtina
Original language name
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Original language description
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age and anatomical location shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We show that stem-like oligodendroglial precursor-like cells, present across all clinico-anatomical groups, display varying levels of maturation dependent on location. We reveal a previously underappreciated relationship between mesenchymal cancer cell states and age, linked to age-dependent differences in the immune microenvironment. Further, we resolve the spatial organization of H3-K27M DMG cell populations and identify a mitotic oligodendroglial-lineage niche. Collectively, our study provides a powerful framework for rational modeling and therapeutic interventions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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