Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00134157" target="_blank" >RIV/00216224:14110/23:00134157 - isvavai.cz</a>
Result on the web
<a href="https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00051-6" target="_blank" >https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00051-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.stemcr.2023.02.004" target="_blank" >10.1016/j.stemcr.2023.02.004</a>

Result language
angličtina
Original language name
Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development
Original language description
Stem cell regulation plays a crucial role during development and homeostasis. Here, an essential source of Wnts from Gli1+ stem/progenitor cells was identified in the murine molar. Loss of Wnt production in Gli1+ apical stem/progenitor cells led to loss of Axin2 at the root apex, mis-regulation of SOX9, loss of BMP and Hh signaling, and truncation of root development. In the absence of Wnt signals, the root epithelium lost its integrity and epithelial identity. This phenotype could be partially mimicked by loss of Sox9 in the Gli1 population. Stabilization of Wnt signaling in the apical papilla led to rapid unordered differentiation of hard tissues and fragmentation of the epithelial root sheath. Wnt signaling from Gli1+ stem/progenitor cells, therefore, orchestrates root development, coordinating mesenchymal and epithelial interactions via SOX9 to regulate stem/progenitor cell expansion and differentiation. Our results demonstrate that disparate stem/progenitor cell populations are unified in their fundamental signaling interactions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
<a href="/en/project/GA23-06160S" target="_blank" >GA23-06160S: Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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