GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00494341" target="_blank" >RIV/68378050:_____/18:00494341 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/s41586-018-0190-3" target="_blank" >http://dx.doi.org/10.1038/s41586-018-0190-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41586-018-0190-3" target="_blank" >10.1038/s41586-018-0190-3</a>

Result language
angličtina
Original language name
GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
Original language description
Wnt-beta-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium by promoting stem cell renewal(1,2). In the small intestine, epithelial Paneth cells secrete Wnt ligands and thus adopt the function of the stem cell niche to maintain epithelial homeostasis(3,4). It is unclear which cells comprise the stem cell niche in the colon. Here we show that subepithelial mesenchymal GLI1-expressing cells form this essential niche. Blocking Wnt secretion from GLI1-expressing cells prevents colonic stem cell renewal in mice: the stem cells are lost and, as a consequence, the integrity of the colonic epithelium is corrupted, leading to death. GLI1-expressing cells also play an important role in the maintenance of the small intestine, where they serve as a reserve Wnt source that becomes critical when Wnt secretion from epithelial cells is prevented. Our data suggest a mechanism by which the stem cell niche is adjusted to meet the needs of the intestine via adaptive changes in the number of mesenchymal GLI1-expressing cells.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/GA18-21466S" target="_blank" >GA18-21466S: Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer: a complex world beyond the cancer-activating mutation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)