Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00135931" target="_blank" >RIV/00216224:14110/24:00135931 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10474323
Result on the web
<a href="https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01408-6" target="_blank" >https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01408-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12964-023-01408-6" target="_blank" >10.1186/s12964-023-01408-6</a>

Result language
angličtina
Original language name
Protein cargo in extracellular vesicles as the key mediator in the progression of cancer
Original language description
Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions.A1Dxc4hLEvJAjvXsZVsCuzVideo Abstract
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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