PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00143508" target="_blank" >RIV/00216224:14110/25:00143508 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0145212625004692?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0145212625004692?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.leukres.2025.108025" target="_blank" >10.1016/j.leukres.2025.108025</a>
Alternative languages
Result language
angličtina
Original language name
PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART
Original language description
Background: Systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK- ALCL) predominantly affects adults, whereas pediatric and young adult ALK- ALCL cases are rare. For adult ALK- ALCL, studies have uncovered recurrent rearrangements of DUSP22 (31%) and VAV1 (16%) and, at lower frequencies, ROS1, TYK2, FRK, and TP63 rearrangements as well as JAK1 and/or STAT3 activating mutations1,2. However, none of these studies included pediatric or young adult patients. Objectives: The aim of this study was to characterize the genetic landscape of pediatric and young adult systemic ALK- ALCL and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (pcCD30+ LPD).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30230 - Other clinical medicine subjects
Result continuities
Project
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Continuities
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Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia Research
ISSN
0145-2126
e-ISSN
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Volume of the periodical
156
Issue of the periodical within the volume
NA
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
1-1
UT code for WoS article
001603165200065
EID of the result in the Scopus database
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