STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074200" target="_blank" >RIV/65269705:_____/21:00074200 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/21:00119058 RIV/00216208:11150/21:10420828 RIV/00179906:_____/21:10420828
Result on the web
<a href="https://www.nature.com/articles/s41375-020-01093-1" target="_blank" >https://www.nature.com/articles/s41375-020-01093-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-020-01093-1" target="_blank" >10.1038/s41375-020-01093-1</a>
Alternative languages
Result language
angličtina
Original language name
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
Original language description
Systemic anaplastic large cell lymphoma (sALCL) encompasses two distinct clinical entities of T-cell non-Hodgkin lymphoma: anaplastic lymphoma kinase-positive (ALK+) ALCL and ALK-negative (ALKMINUS SIGN ) ALCL. These entities are characterized by either the presence or absence of an ALK translocation. It has been reported that ALK+ ALCL has a better prognosis compared to ALKMINUS SIGN , with a 5-year overall survival (OS) of 70-80% versus 40-60%, respectively, [1,2,3]. Furthermore, more than 30% of ALK+ ALCL patients relapse [4, 5]. In this study, the mutational landscape of sALCL patient tumors was investigated to discover potential biomarkers that may improve risk stratification and patient management.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
1500-1505
UT code for WoS article
000593816000001
EID of the result in the Scopus database
2-s2.0-85096875485