THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F94%3A00035805" target="_blank" >RIV/00216224:14110/94:00035805 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Original language description
A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cellsto tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
1994
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
ISSN
0009-9104
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
A1994MU82700003
EID of the result in the Scopus database
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