Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F20%3A00118236" target="_blank" >RIV/00216224:14160/20:00118236 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s13167-020-00210-5" target="_blank" >https://link.springer.com/article/10.1007/s13167-020-00210-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13167-020-00210-5" target="_blank" >10.1007/s13167-020-00210-5</a>
Alternative languages
Result language
angličtina
Original language name
Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
Original language description
Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EPMA JOURNAL
ISSN
1878-5077
e-ISSN
1878-5085
Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
27
Pages from-to
261-287
UT code for WoS article
000538040300009
EID of the result in the Scopus database
2-s2.0-85085874618