All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00127132" target="_blank" >RIV/00216224:14160/22:00127132 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug

  • Original language description

    To avoid standard therapies for gastrointestinal inflammatory diseases, an interest in finding new alternatives is rising. Plant monoterpene substances, such as thymol, carvacrol, eugenol, etc., exhibit many valuable biological activities in treating intestinal inflammation. The basic problem is that monoterpenes are volatile hydrophobic substances with poor oral bioavailability. Thymol is only partially absorbed mainly from the stomach, resulting in a 16% bioavailability. It is cumulated in a higher amount of intestinal mucosa. Thymol could be incorporated into solid self-emulsifying (SE) pellets with gastro-resistant properties to overcome drawbacks and support intestinal wall cumulation. During pellets formulation by extrusion/spheronisation, liquid and solid phases are in temporary or permanent contact. It opens the scope for interactions, instabilities, and components transfer within the dosage form. Therefore, a deep investigation of such a system by solid-state nuclear magnetic resonance spectroscopy (ss-NMR) is also necessary. ss-NMR spectroscopy confirms that thymol and SES molecules forms homogenous liquid films/phases on the surface. A more detailed investigation revealed that the thymol molecules in the uncoated sample with long-time prepareation exhibited lower molecular dynamics compared to shorter methods, indicating a higher impact of interactions between the Neusilin surface and drug.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

    <a href="/en/project/GA22-03187S" target="_blank" >GA22-03187S: Rational Design of Polysaccharide‐based Particulate Systems for the Delivery of Mucosal Therapeutics with Broad Spectrum of Biological Activities</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů