IMAGING OF ELEMENTS AND PROTEINS IN BIOLOGICAL TISSUES: MEDICAL AND PHARMACEUTICAL APPLICATIONS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00129198" target="_blank" >RIV/00216224:14160/22:00129198 - isvavai.cz</a>
Result on the web
<a href="https://www.pharm.muni.cz/veda-a-vyzkum/sal-2022/attendee-information" target="_blank" >https://www.pharm.muni.cz/veda-a-vyzkum/sal-2022/attendee-information</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
IMAGING OF ELEMENTS AND PROTEINS IN BIOLOGICAL TISSUES: MEDICAL AND PHARMACEUTICAL APPLICATIONS
Original language description
In the last decades, increased interest in imaging of elements/metals/proteins distribution, mainly in pharmaceutical, biomedicine research, or life science with direct application of research to specific problem/disease [1-3]. The main emphasis of this contribution is to demonstrate the unique method of laser ablation with inductively coupled plasma and mass spectrometry (LA-ICP-MS). It is a well-established method for multi-elemental analysis of elements at trace and ultra-trace. Nowadays, it is also starting to be used as a technique for the simultaneous specific determination of the protein of interest, which opens up the possibility of achieving the so-called multiplex analysis. Proteins are imaged using an immunohistochemical method (binding nanoparticle-labeled antibodies to a specific protein) and LA-ICP-MS. The main advantages of utilizing LA-ICP-MS are the acquisition of comprehensive (Metallo)proteomic information about the tissue of a given disease (in this case, cancer or stroke) or low detection limits compared to other conventionally employed protein imaging techniques in combination with multiplex analysis of one sample.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů