BIOIMAGING OF ELEMENTS AND PROTEINS BY LA-ICP-MS IN MEDICINE AND PHARMACEUTICAL RESEARCH

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00129429" target="_blank" >RIV/00216224:14310/22:00129429 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
BIOIMAGING OF ELEMENTS AND PROTEINS BY LA-ICP-MS IN MEDICINE AND PHARMACEUTICAL RESEARCH
Original language description
In the last decades, increased interest in imaging of elements/metals/proteins distribution, mainly in pharmaceutical, biomedicine research, or life science with direct application of research to specific problem/disease. The main emphasis of this contribution is to demonstrate the unique method of laser ablation with inductively coupled plasma and mass spectrometry (LA-ICP-MS) not only as a method of element analysis, but also as a technique for the simultaneous specific determination of the protein of interest, which opens up the possibility of achieving the so-called multiplex analysis. Proteins are imaged using a combination of immunohistochemical methods – binding of nanoparticles labeled antibodies to a specific protein. The main advantages of using LA-ICP-MS are not only the acquisition of complex (metallo)proteomic information about the tissue of a given disease (in this case, cancer or stroke), but also low detection limits compared to other conventionally used protein imaging techniques, or multiplex analysis of a single sample.
Czech name
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Czech description
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Project
<a href="/en/project/GA20-02203S" target="_blank" >GA20-02203S: Analysis of tissue response to metal nanoparticles inhalation and mechanisms of their clearance</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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