Paulownia tomentosa extracts fighting against staphylococcal biofilm formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00131050" target="_blank" >RIV/00216224:14160/23:00131050 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Paulownia tomentosa extracts fighting against staphylococcal biofilm formation
Original language description
Staphylococcus aureus is challenging to treat especially if biofilm occurs. Prenylated phenolics provide a significant source of potent antimicrobial agents. Ethanolic extract of Paulownia tomentosa was rich in active compounds, but prenylated flavonoids were dominant in the chloroform fraction. MIC of ethanolic extract, chloroform fraction, and three flavonoids showed significant antimicrobial activity, while lower concentrations prolonged the lag phase. Selected compounds reduced the adhesion of bacteria to the abiotic surface, and also the measurement of bioluminescence showed inhibition of intercellular signaling in bacterial suspension treated with plant formulations.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů